Oldham are set to be without full-back Paul Black for the visit of Tranmere.
Black suffered a hamstring injury during last Saturday's 5-0 drubbing at MK Dons and, although the club are still waiting on the results of a scan, he is expected to be sidelined for a number of weeks.
Captain Dean Furman has stepped up training following a knee problem and will be assessed again on Friday before a decision is made on his return to the midfield.
Latics manager Paul Dickov is set to include Reuben Reid in his squad, with the striker coming through a reserve outing against Burnley in midweek following a lengthy absence with a thigh injury.
In the same game, Reid's fellow forward Matt Smith bagged a brace to give Dickov further food for thought in attack.
Kirk Millar damaged ankle ligaments against the Clarets' second string and is ruled out this weekend. The winger will have a scan once the swelling has gone down.
Enoch Showunmi and Andy Robinson are set to return to Tranmere's squad.
The forward duo are back in full training following respective leg and knee problems and played 90 minutes against Manchester City reserves on Monday night.
Showunmi's injury has kept him away from first-team duties since the turn of the year, while Robinson last played in mid-December.
Rovers manager Les Parry told the club's official website: "Both played another 90 minutes on Monday for the reserves. They both showed great attitude.
"They didn't just get through the game, they put in a lot of hard work and I was made up to see that. So they are both in contention for Saturday."
Stoke striker Ryan Brunt's loan spell expires after the game, while defenders David Raven (groin) and Zoumana Bakayogo (shin) remain sidelined.