Leaders Southampton hope to welcome back top scorer Rickie Lambert for the derby showdown with Portsmouth.
Lambert missed last weekend's 3-0 defeat by Blackpool after aggravating a groin injury in training, but manager Nigel Adkins is "optimistic" his 28-goal striker will be fit.
Saints were short in attack at Bloomfield Road as Japan international Tadanari Lee was also out with a foot injury which could keep him sidelined for the rest of the season.
Frazer Richardson was also missing due to a knock and will be assessed with Danny Butterfield on stand-bay to continue at right-back.
Skipper Dean Hammond is pushing for a return to the starting line-up in midfield after he was left on the bench at Blackpool.
George Thorne will, meanwhile, be missing for Portsmouth when they make the short trip to face their fierce derby rivals.
Teenage midfielder Thorne, who is on loan from West Brom, has been ruled out for the rest of the season after suffering an ankle injury against Burnley last weekend.
Manchester City loanee Luca Scapuzzi came on for Thorne and could now be in line for his full debut after two substitute appearances.
Boss Michael Appleton must decide whether to make further changes after the 5-1 defeat by the Clarets left Pompey five points adrift of safety.
But he is likely to be without defender Aaron Mokoena (ankle) and striker Kanu (back) again.
Chris Maguire starts in attack after extending his loan from Derby.