The 22-year-old failed to make an impact in his first season at Old Trafford, then spent last term on loan at Besiktas for a campaign blighted by injury troubles.
Injured defenders Chris Smalling and Jonny Evans are notable absentees, but new signing Shinji Kagawa will get the chance to impress.
Rio Ferdinand will captain a squad which includes senior players Michael Carrick, Paul Scholes and Javier Hernandez as well as a host of youngsters.
The players will fly out to Durban on Monday morning for a tour which also takes in Cape Town and Shanghai.
Squad: Lindegaard, Amos, Johnstone; Ferdinand, Veseli, Vermijl, Wootton, Blackett; Valencia, Anderson, Carrick, Scholes, Powell, Kagawa, Bebe, Tunnicliffe, Lingard, Brady, Petrucci; Berbatov, Hernandez, Macheda.